in a mouse model, giving genetic validation of CRK12:CYC9 as a novel drug target for trypanosomiasis. Even more, useful characterisation of CRK12 and CYC9 utilizing RNA interference reveals roles for these proteins in endocytosis and cytokinesis, respectively.. Gene expression regulation by CDK12: a flexible kinase in cancer with functions over and
, a kinetoplastid protozoan parasite which belongs towards the get of trypanosomatids together with Trypanosoma bruceiLister 427 cells. Trypanosomes were being transfected with Just about every plasmid individually, and after that subjected to the second transfection with one of the other plasmids, with a special resistance gene, with all pairwise
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